Recent Publications
-The relative rate of kill of the MMV Malaria Box compounds provide links to the mode of antimalarial action and highlight scaffolds of medicinal chemistry interest. Ullah, Imran; Sharma, Raman; Mete, Antonio; Biagini, Giancarlo; Wetzel, Dawn; Horrocks, Paul; Journal of Antimicrobial Chemotherapy, Volume 75 (2), 2020, Pages 362–370.
-Discovery of AZD-2098 and AZD-1678; Two - Potent and Bioavailable CCR4 Receptor Antagonists. Kindon, Nicholas; Mete, Antonio, et al. ACS Medicinal Chemistry Letters 2017 DOI:10.1021/acsmedchemlett.7b00315.
- The relationship between the 'Rate of Kill' of discovery antimalarial compounds and their chemical structure and mode of action. Antonio Mete, Imran Ullah & Paul Horrocks; Poster presented at 19th RSC/SCI Medicinal Chemistry Symposium, Cambridge, UK on 10-13th Sept, 2017.
- Cathepsin C inhibitors: Property optimization and identification of a clinical candidate. Furber, Mark; Gardiner, Philip; Tiden, Anna-Karin; Mete, Antonio; Ford, Rhonan; Millichip, Ian; Stein, Linda; Mather, Andrew; Kinchin, Elizabeth; Luckhurst, Christopher et al. Journal of Medicinal Chemistry 2014, 57, 2357-67.
- The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD. Mete, Antonio; Bowers, Keith; Bull, Richard J.; Coope, Helen; Donald, David K.; Escott, Katherine J.; Ford, Rhonan; Grime, Ken; Mather, Andrew; Ray, Nicholas C. Bioorganic & Medicinal Chemistry Letters , 2013, 23(23), 6248-6253.
-The relative rate of kill of the MMV Malaria Box compounds provide links to the mode of antimalarial action and highlight scaffolds of medicinal chemistry interest. Ullah, Imran; Sharma, Raman; Mete, Antonio; Biagini, Giancarlo; Wetzel, Dawn; Horrocks, Paul; Journal of Antimicrobial Chemotherapy, Volume 75 (2), 2020, Pages 362–370.
-Discovery of AZD-2098 and AZD-1678; Two - Potent and Bioavailable CCR4 Receptor Antagonists. Kindon, Nicholas; Mete, Antonio, et al. ACS Medicinal Chemistry Letters 2017 DOI:10.1021/acsmedchemlett.7b00315.
- The relationship between the 'Rate of Kill' of discovery antimalarial compounds and their chemical structure and mode of action. Antonio Mete, Imran Ullah & Paul Horrocks; Poster presented at 19th RSC/SCI Medicinal Chemistry Symposium, Cambridge, UK on 10-13th Sept, 2017.
- Cathepsin C inhibitors: Property optimization and identification of a clinical candidate. Furber, Mark; Gardiner, Philip; Tiden, Anna-Karin; Mete, Antonio; Ford, Rhonan; Millichip, Ian; Stein, Linda; Mather, Andrew; Kinchin, Elizabeth; Luckhurst, Christopher et al. Journal of Medicinal Chemistry 2014, 57, 2357-67.
- The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD. Mete, Antonio; Bowers, Keith; Bull, Richard J.; Coope, Helen; Donald, David K.; Escott, Katherine J.; Ford, Rhonan; Grime, Ken; Mather, Andrew; Ray, Nicholas C. Bioorganic & Medicinal Chemistry Letters , 2013, 23(23), 6248-6253.
Publications by Biological Targets:
GPCR Antagonists: Chemokine, Muscarinic and Nicotinic Receptors
- Discovery of AZD-2098 and AZD-1678; Two Potent and Bioavailable CCR4 Receptor Antagonists. Kindon, Nicholas; Mete, Antonio, et al. ACS Medicinal Chemistry Letters 2017 DOI:10.1021/acsmedchemlett.7b00315.
- The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD. Mete, Antonio; Bowers, Keith; Bull, Richard J.; Coope, Helen; Donald, David K.; Escott, Katherine J.; Ford, Rhonan; Grime, Ken; Mather, Andrew; Ray, Nicholas C. Bioorganic & Medicinal Chemistry Letters , 2013, 23(23), 6248-6253.
- The discovery of AZD9164, a novel muscarinic M3 antagonist. Mete, Antonio; Bowers, Keith; Chevalier, Eric; Donald, David K.; Edwards, Helen; Escott, Katherine J.; Ford, Rhonan; Grime, Ken; Millichip, Ian; Teobald, Barry; et al. Bioorganic & Medicinal Chemistry Letters, 2011, 21(24), 7440-7446. http://www.sciencedirect.com/science/article/pii/S0960894X11013904
- Preparation of 1-azabicyclo[2.2.2]octane derivatives as muscarinic receptor antagonists. Ford, Rhonan Lee; Mete, Antonio; Millichip, Ian; Teobald, Barry John; Kinchin, Elizabeth Claire; PCT Int. Appl. 2009, WO 2009153536.
- (R)-1-Azabicyclo[2.2.2]octane salts and benzothiazole derivatives as muscarinic receptor antagonists and b2-adrenoceptor agonists and their preparation, pharmaceutical compositions and use in the treatment of respiratory,diseases. Mete, Antonio; Millichip, Ian; Wiley, Katherine; PCT Int. Appl. 2009, WO 2009154555.
- Quinuclidine derivatives and their use as muscarinic receptor antagonists. Ford, Rhonan; Mete, Antonio; Millichip, Ian; PCT Int. Appl. 2009, WO 2009139710.
- Quinuclidine derivatives and their use as muscarinic receptor antagonists for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Mather, Andrew; Mete, Antonio; Millichip, Ian; PCT Int. Appl. 2009, WO 2009139709.
- Pharmaceutical product comprising muscarinic receptor antagonist and b2-adrenoceptor agonist for treatment of respiratory diseases. Bull, Richard; Ford, Rhonan; Mather, Andrew; Mete, Antonio; Wiley, Katherine; PCT Int. Appl. 2009, WO 2009139708.
- Pharmaceutical product comprising muscarinic receptor antagonist and second active ingredient for treatment of respiratory diseases such as chronic obstructive pulmonary disease and asthma. Bull, Richard; Ford, Rhonan; Mather, Andrew; Mete, Antonio; PCT Int. Appl. 2009, WO 2009139707.
- Quinuclidine derivatives as muscarinic M3 receptor antagonists. Ford, Rhonan Lee; Mather, Andrew Nigel; Mete, Antonio; Bull, Richard James; Skidmore, Elizabeth Anne; PCT Int. Appl. 2009, WO 2009138707.
- From HTS hit to CD: Optimization of a novel series of CCR4 antagonists. Mete, Antonio; Andrews, Glen; Baxter, Andrew; Cheshire, David; Ewart, Lorna; Harper, Steve; Hickling, Kevin; Kindon, Nicholas; McGinnity, Dermot; Murray, Claire; et al. Abstracts of Papers, 238th ACS National Meeting, Washington, DC, United States, August 16-20, 2009.
- Preparation of piperidinium compounds as muscarinic acetylcholine M3 receptor antagonists for treatment of chronic obstructive pulmonary diseases. Ford, Rhonan; Mete, Antonio; Millichip, Ian PCT Int. Appl. 2008, WO 2008075006.
- Quinuclidinol derivatives as muscarinic receptor antagonists. Ford, Rhonan; Mete, Antonio; Millichip, Ian; Teobald, Barry; PCT Int. Appl. 2008, WO 2008075005.
- Preparation of cycloheptylcarbonyloxypiperidinium and pyrrolidinium salts for treatment of chronic obstructive pulmonary disease.
Ford, Rhonan; Mather, Andrew; Mete, Antonio; PCT Int. Appl. 2008, WO 2008059239.
- Preparation of quinuclidine derivatives as muscarinic receptor antagonists. Ford, Rhonan; Mather, Andrew; Mete, Antonio; PCT Int. Appl. 2008, WO 2008059245.
- Preparation of oxadiazoles and thiazoles as muscarinic M3 receptor ligands. Bull, Richard James; Van den Heuvel, Marco; Mete, Antonio; Nadin, Alan John; Ray, Nicholas Charles; PCT Int. Appl. 2008, WO 2008023157.
- Preparation of 1,1-dialkylpiperidinium derivatives as muscarinic receptor antagonists. Bailey, Andrew; Mete, Antonio; Pairaudeau, Garry; Stocks, Michael; Wenlock, Mark; PCT Int. Appl. 2007, WO 2007123465.
- Preparation of N-(fluoropyrazinyl)phenylsulfonamides as modulators of chemokine receptor CCR4. Cheshire, David; Kindon, Nicholas; Mete, Antonio; Roberts, Bryan; PCT Int. Appl. 007, WO 2007069978.
- Preparation of N-pyrazinyl phenylsulfonamides as chemokine receptor modulators for treatment of asthma. Kindon, Nicholas; Mete, Antonio; Teobald, Barry; PCT Int. Appl. 2007, WO 2007035154.
- Preparation of sulfonamide compounds that modulate chemokine receptor activity (CCR4). Mete, Antonio; Teobald, Barry; PCT Int. Appl. 2004, WO 2004108717.
- Preparation of N-pyrazinyl arylsulfonamides that modulate chemokine (CCR4) receptor activity. Harrison, Richard; Mete, Antonio; Teobald, Barry; Walters, Iain; PCT Int. Appl. 2004, WO 2004108692.
- Preparation of methylene-substituted heterocyclic insecticides and acaricides. Mete, Antonio; Mankee, Jamie Brian; Eur. Pat. Appl. 1995,
EP 652215.
- Preparation of N-(3-fluorobenzyl)heterocyclic derivatives and their use as pesticides. Davies, Sarah Anne; Mankee, Jamie Brian; Mete, Antonio; Eur. Pat. Appl.1994, EP 623601.
- Heterocyclic molluscicides. Mete, Antonio; Munro, David; Badmin, John Stewart; Patel, Bipin; Mankee, Jamie Brian; Davies, Sarah Anne; Eur. Pat. Appl. 1994, EP 617893.
- Specific Uptake of [22,23 3H2] Dihydro-Azadirachtin from the Haemolymph of Schistocerca gregaria. Poster at Advances in the Chemistry of Insect Control, SCI, Cambridge, 1993.
- Preparation of heterocyclic nitromethylene derivatives for aphid control. Mete, Antonio; Brit. UK Pat. Appl. 1993,GB 2263640.
- Preparation of 1-[(heterocyclylmethyl)amino]-1-amino-1-buten-3-ones and analogues as pesticides. Mete, Antonio; Chan, Lai Chun; Eur. Pat. Appl. 1991, EP 425030.
GPCR Antagonists: Chemokine, Muscarinic and Nicotinic Receptors
- Discovery of AZD-2098 and AZD-1678; Two Potent and Bioavailable CCR4 Receptor Antagonists. Kindon, Nicholas; Mete, Antonio, et al. ACS Medicinal Chemistry Letters 2017 DOI:10.1021/acsmedchemlett.7b00315.
- The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD. Mete, Antonio; Bowers, Keith; Bull, Richard J.; Coope, Helen; Donald, David K.; Escott, Katherine J.; Ford, Rhonan; Grime, Ken; Mather, Andrew; Ray, Nicholas C. Bioorganic & Medicinal Chemistry Letters , 2013, 23(23), 6248-6253.
- The discovery of AZD9164, a novel muscarinic M3 antagonist. Mete, Antonio; Bowers, Keith; Chevalier, Eric; Donald, David K.; Edwards, Helen; Escott, Katherine J.; Ford, Rhonan; Grime, Ken; Millichip, Ian; Teobald, Barry; et al. Bioorganic & Medicinal Chemistry Letters, 2011, 21(24), 7440-7446. http://www.sciencedirect.com/science/article/pii/S0960894X11013904
- Preparation of 1-azabicyclo[2.2.2]octane derivatives as muscarinic receptor antagonists. Ford, Rhonan Lee; Mete, Antonio; Millichip, Ian; Teobald, Barry John; Kinchin, Elizabeth Claire; PCT Int. Appl. 2009, WO 2009153536.
- (R)-1-Azabicyclo[2.2.2]octane salts and benzothiazole derivatives as muscarinic receptor antagonists and b2-adrenoceptor agonists and their preparation, pharmaceutical compositions and use in the treatment of respiratory,diseases. Mete, Antonio; Millichip, Ian; Wiley, Katherine; PCT Int. Appl. 2009, WO 2009154555.
- Quinuclidine derivatives and their use as muscarinic receptor antagonists. Ford, Rhonan; Mete, Antonio; Millichip, Ian; PCT Int. Appl. 2009, WO 2009139710.
- Quinuclidine derivatives and their use as muscarinic receptor antagonists for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Mather, Andrew; Mete, Antonio; Millichip, Ian; PCT Int. Appl. 2009, WO 2009139709.
- Pharmaceutical product comprising muscarinic receptor antagonist and b2-adrenoceptor agonist for treatment of respiratory diseases. Bull, Richard; Ford, Rhonan; Mather, Andrew; Mete, Antonio; Wiley, Katherine; PCT Int. Appl. 2009, WO 2009139708.
- Pharmaceutical product comprising muscarinic receptor antagonist and second active ingredient for treatment of respiratory diseases such as chronic obstructive pulmonary disease and asthma. Bull, Richard; Ford, Rhonan; Mather, Andrew; Mete, Antonio; PCT Int. Appl. 2009, WO 2009139707.
- Quinuclidine derivatives as muscarinic M3 receptor antagonists. Ford, Rhonan Lee; Mather, Andrew Nigel; Mete, Antonio; Bull, Richard James; Skidmore, Elizabeth Anne; PCT Int. Appl. 2009, WO 2009138707.
- From HTS hit to CD: Optimization of a novel series of CCR4 antagonists. Mete, Antonio; Andrews, Glen; Baxter, Andrew; Cheshire, David; Ewart, Lorna; Harper, Steve; Hickling, Kevin; Kindon, Nicholas; McGinnity, Dermot; Murray, Claire; et al. Abstracts of Papers, 238th ACS National Meeting, Washington, DC, United States, August 16-20, 2009.
- Preparation of piperidinium compounds as muscarinic acetylcholine M3 receptor antagonists for treatment of chronic obstructive pulmonary diseases. Ford, Rhonan; Mete, Antonio; Millichip, Ian PCT Int. Appl. 2008, WO 2008075006.
- Quinuclidinol derivatives as muscarinic receptor antagonists. Ford, Rhonan; Mete, Antonio; Millichip, Ian; Teobald, Barry; PCT Int. Appl. 2008, WO 2008075005.
- Preparation of cycloheptylcarbonyloxypiperidinium and pyrrolidinium salts for treatment of chronic obstructive pulmonary disease.
Ford, Rhonan; Mather, Andrew; Mete, Antonio; PCT Int. Appl. 2008, WO 2008059239.
- Preparation of quinuclidine derivatives as muscarinic receptor antagonists. Ford, Rhonan; Mather, Andrew; Mete, Antonio; PCT Int. Appl. 2008, WO 2008059245.
- Preparation of oxadiazoles and thiazoles as muscarinic M3 receptor ligands. Bull, Richard James; Van den Heuvel, Marco; Mete, Antonio; Nadin, Alan John; Ray, Nicholas Charles; PCT Int. Appl. 2008, WO 2008023157.
- Preparation of 1,1-dialkylpiperidinium derivatives as muscarinic receptor antagonists. Bailey, Andrew; Mete, Antonio; Pairaudeau, Garry; Stocks, Michael; Wenlock, Mark; PCT Int. Appl. 2007, WO 2007123465.
- Preparation of N-(fluoropyrazinyl)phenylsulfonamides as modulators of chemokine receptor CCR4. Cheshire, David; Kindon, Nicholas; Mete, Antonio; Roberts, Bryan; PCT Int. Appl. 007, WO 2007069978.
- Preparation of N-pyrazinyl phenylsulfonamides as chemokine receptor modulators for treatment of asthma. Kindon, Nicholas; Mete, Antonio; Teobald, Barry; PCT Int. Appl. 2007, WO 2007035154.
- Preparation of sulfonamide compounds that modulate chemokine receptor activity (CCR4). Mete, Antonio; Teobald, Barry; PCT Int. Appl. 2004, WO 2004108717.
- Preparation of N-pyrazinyl arylsulfonamides that modulate chemokine (CCR4) receptor activity. Harrison, Richard; Mete, Antonio; Teobald, Barry; Walters, Iain; PCT Int. Appl. 2004, WO 2004108692.
- Preparation of methylene-substituted heterocyclic insecticides and acaricides. Mete, Antonio; Mankee, Jamie Brian; Eur. Pat. Appl. 1995,
EP 652215.
- Preparation of N-(3-fluorobenzyl)heterocyclic derivatives and their use as pesticides. Davies, Sarah Anne; Mankee, Jamie Brian; Mete, Antonio; Eur. Pat. Appl.1994, EP 623601.
- Heterocyclic molluscicides. Mete, Antonio; Munro, David; Badmin, John Stewart; Patel, Bipin; Mankee, Jamie Brian; Davies, Sarah Anne; Eur. Pat. Appl. 1994, EP 617893.
- Specific Uptake of [22,23 3H2] Dihydro-Azadirachtin from the Haemolymph of Schistocerca gregaria. Poster at Advances in the Chemistry of Insect Control, SCI, Cambridge, 1993.
- Preparation of heterocyclic nitromethylene derivatives for aphid control. Mete, Antonio; Brit. UK Pat. Appl. 1993,GB 2263640.
- Preparation of 1-[(heterocyclylmethyl)amino]-1-amino-1-buten-3-ones and analogues as pesticides. Mete, Antonio; Chan, Lai Chun; Eur. Pat. Appl. 1991, EP 425030.
Enzyme Inhibitors: Proteases, Lipases and Nitric Oxide Synthase
- Cathepsin C inhibitors: Property optimization and identification of a clinical candidate. Furber, Mark; Gardiner, Philip; Tiden, Anna-Karin; Mete, Antonio; Ford, Rhonan; Millichip, Ian; Stein, Linda; Mather, Andrew; Kinchin, Elizabeth; Luckhurst, Christopher; et al. Journal of Medicinal Chemistry 2014, 57, 2357-67.
- A potent, stable cathepsin C inhibitor with a step change in properties achieved through lead hopping. Tiden, Anna-Karin, Mete, Antonio; et al. Poster presented at 17th RSC/SCI Medicinal Chemistry Symposium, Cambridge, UK on 8-11th September, 2013. http://tinyurl.com/ouq66cs
- Preparation of cyclohexanecarboxamide compounds as DPP1 inhibitors. Ford, Rhonan; Kinchin, Elizabeth; Mather, Andrew; Mete, Antonio; Millichip, Ian; Stanier, Andrew Geoffrey; PCT Int. Appl. 2011, WO 2011154677.
- Design of novel and potent cPLA2a inhibitors containing an a-methyl-2-ketothiazole as a metabolically stable serine trap. Mete, Antonio; Andrews, Glen; Bernstein, Mike; Connolly, Stephen; Hartopp, Paul; Jackson, Clive G.; Lewis, Richard; Martin, Iain; Murray, David; Riley, Rob; et al. Bioorganic & Medicinal Chemistry Letters, 2011, 21(10), 3128-3133. http://www.sciencedirect.com/science/article/pii/S0960894X11003167
- The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS). Cheshire, David R.; Aberg, Anders; Andersson, Gunilla M. K.; Andrews, Glen; Beaton, Haydn G.; Birkinshaw, Timothy N.; Boughton-Smith, Nigel; Connolly, Stephen; Cook, Tony R.; Cooper, Anne; Mete, Antonio; et al. Bioorganic & Medicinal Chemistry Letters, 2011, 21(8), 2468-2471. http://www.sciencedirect.com/science/article/pii/S0960894X11002459
- Substituted N-[1-cyano-2-(phenyl)ethyl] piperidin-2-ylcarboxmide compounds as DPP1 inhibitors and their preparation and use in the treatment of diseases. Mete, Antonio; PCT Int. Appl. 2010, WO 2010142985.
- Preparation of cyanoethyltetrahydropyrancarboxamide derivatives for use as DPP1 modulators. Ford, Rhonan; Mete, Antonio; Mather, Andrew; Millichip, Ian; PCT Int. Appl. 2010, WO 2010128324.
- Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Garcin, Elsa D.; Arvai, Andrew S.; Rosenfeld, Robin J.; Kroeger, Matt D.; Crane, Brian R.; Andersson, Gunilla; Andrews, Glen; Hamley, Peter J.; Mallinder, Philip R.; Nicholls, David J.; Mete, Antonio; et al. Nature Chemical Biology, 2008, 4(11), 700-707. http://www.nature.com/nchembio/journal/v4/n11/abs/nchembio.115.html
- Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors--reducing the lipophilicity of the arachidonyl chain isostere. Walters, Iain; Bennion, Colin; Connolly, Stephen; Croshaw, Pamela J.; Hardy, Kim; Hartopp, Paul; Jackson, Clive G.; King, Sarah J.; Lawrence, Louise; Mete, Antonio; et al. Bioorganic & Medicinal Chemistry Letters, 2004, 14(14), 3645-3649. http://www.sciencedirect.com/science/article/pii/S0960894X04006596
- Preparation of aminohydroxyalkylthiothiophenecarbonitriles as nitric oxide synthase (NOS) inhibitors. Mete, Antonio; Walters, Iain; PCT Int. Appl. 2004, WO 2004009580.
- Preparation of 3-[((1S)-2-amino-1-phenylethyl)thio]-5-methyl-2-thiophenecarbonitrile oxalate and related compounds as nitric oxide synthase inhibitors. Mete, Antonio; Walters, Iain; PCT Int. Appl. 2004, WO 2004009579.
- Inhibitors of the NOS enzymes: a patent review. Mete, Antonio; Connolly, Stephen; IDrugs, 2003, 6(1), 57-65. http://www.ncbi.nlm.nih.gov/pubmed/12789622
- Preparation of heteroarylheteroalkylamines as inhibitors of nitric oxide synthase. Chen, Deborah; Cheshire, David; Connolly, Stephen; Mete, Antonio; PCT Int. Appl. 2003, WO 2003011831.
- Preparation of heteroarylheteroalkylamines as inhibitors of nitric oxide synthase. Birkinshaw, Timothy; Cheshire, David; ConnollyStephen; Luker, Timothy; Mete, Antonio; PCT Int. Appl.2003, WO 2003011830.
- Preparation of (hetero)arylheteroalkylamines as inhibitors of nitric oxide synthase. Cheshire, David; Connolly, Stephen; Mete, Antonio; PCT Int. Appl. 2003, WO 2003011210.
- Preparation of arylheteroalkylamine derivatives as nitric oxide synthase inhibitors useful as anti-inflammatories and analgesics.
Birkinshaw, Tim; Connolly, Stephen; Luker, Timothy; Mete, Antonio; Millichip, Ian; PCT Int. Appl. 2002, WO 2002090332.
- Preparation of phenylheteroazetidines useful as nitric oxide synthase inhibitors. Cheshire, David; Luker, Timothy; Mete, Antonio; PCT Int. Appl. 2002, WO 2002012187.
- Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 based on a 1,3-Disubstituted Propan-2-one Skeleton. Connolly, Stephen; Bennion, Colin; Botterell, Sarah; Croshaw, Pamela J.; Hallam, Catherine; Hardy, Kim; Hartopp, Paul; Jackson, Clive G.; King, Sarah J.; Lawrence, Louise; Mete, Antonio; et al. Journal of Medicinal Chemistry,2002, 45(6), 1348-1362. http://pubs.acs.org/doi/abs/10.1021/jm011050x?prevSearch=%255BContrib%253A%2Bmete%255D&searchHistoryKey
- Preparation of novel phenylheteroalkylamines as inhibitors of nitric oxide synthase. Cheshire, David; Connolly, Stephen; Cox, David; Mete, Antonio; PCT Int. Appl. 2001, WO 2001062714.
- Preparation of novel phenylheteroalkylamines as inhibitors of nitric oxide synthase. Birkinshaw, Tim; Cheshire, David; Mete, Antonio; PCT Int. Appl. 2001, WO 2001062713.
- Preparation of phenylheteroalkylamines as inhibitors of nitric oxide synthase. Cheshire, David; Connolly, Stephen; Cox, David; Hamley, Peter; Mete, Antonio; Pimm, Austen; PCT Int. Appl.2001, WO 2001062704.
- Preparation of 5,7-bicyclic amidine derivatives useful as nitric oxide synthase inhibitors. Cheshire, David; Connolly, Stephen; Cox, David; Hamley, Peter; Luker, Timothy; Mete, Antonio; Pimm, Austen; Stocks, Michael; PCT Int. Appl. 2000, WO 2000064904.
- 1,3-Disubstituted Propan-2-ones: A Novel Series of Potent Inhibitors of cPLA2. Mete, Antonio; Connolly, Stephen; et al. Poster at XVth EFMC International Symposium on Medicinal Chemistry, Edinburgh, 1998. (Reviewed in: Drugs of the Future, 2000, 25(8), 823-32).
- Preparation of aryloxyacyl thiazoles and their analogs as anti-inflammatory agents. Mete, Antonio; Connolly, Stephen; PCT Int. Appl. 2000, WO2000034254.
- Transition State Analogues as Inhibitors of cPLA2. Mete, Antonio; Connolly, Stephen; et al. Lecture at East of England Medicinal Chemistry Symposium, Hatfield, 1998.
- Cathepsin C inhibitors: Property optimization and identification of a clinical candidate. Furber, Mark; Gardiner, Philip; Tiden, Anna-Karin; Mete, Antonio; Ford, Rhonan; Millichip, Ian; Stein, Linda; Mather, Andrew; Kinchin, Elizabeth; Luckhurst, Christopher; et al. Journal of Medicinal Chemistry 2014, 57, 2357-67.
- A potent, stable cathepsin C inhibitor with a step change in properties achieved through lead hopping. Tiden, Anna-Karin, Mete, Antonio; et al. Poster presented at 17th RSC/SCI Medicinal Chemistry Symposium, Cambridge, UK on 8-11th September, 2013. http://tinyurl.com/ouq66cs
- Preparation of cyclohexanecarboxamide compounds as DPP1 inhibitors. Ford, Rhonan; Kinchin, Elizabeth; Mather, Andrew; Mete, Antonio; Millichip, Ian; Stanier, Andrew Geoffrey; PCT Int. Appl. 2011, WO 2011154677.
- Design of novel and potent cPLA2a inhibitors containing an a-methyl-2-ketothiazole as a metabolically stable serine trap. Mete, Antonio; Andrews, Glen; Bernstein, Mike; Connolly, Stephen; Hartopp, Paul; Jackson, Clive G.; Lewis, Richard; Martin, Iain; Murray, David; Riley, Rob; et al. Bioorganic & Medicinal Chemistry Letters, 2011, 21(10), 3128-3133. http://www.sciencedirect.com/science/article/pii/S0960894X11003167
- The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS). Cheshire, David R.; Aberg, Anders; Andersson, Gunilla M. K.; Andrews, Glen; Beaton, Haydn G.; Birkinshaw, Timothy N.; Boughton-Smith, Nigel; Connolly, Stephen; Cook, Tony R.; Cooper, Anne; Mete, Antonio; et al. Bioorganic & Medicinal Chemistry Letters, 2011, 21(8), 2468-2471. http://www.sciencedirect.com/science/article/pii/S0960894X11002459
- Substituted N-[1-cyano-2-(phenyl)ethyl] piperidin-2-ylcarboxmide compounds as DPP1 inhibitors and their preparation and use in the treatment of diseases. Mete, Antonio; PCT Int. Appl. 2010, WO 2010142985.
- Preparation of cyanoethyltetrahydropyrancarboxamide derivatives for use as DPP1 modulators. Ford, Rhonan; Mete, Antonio; Mather, Andrew; Millichip, Ian; PCT Int. Appl. 2010, WO 2010128324.
- Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Garcin, Elsa D.; Arvai, Andrew S.; Rosenfeld, Robin J.; Kroeger, Matt D.; Crane, Brian R.; Andersson, Gunilla; Andrews, Glen; Hamley, Peter J.; Mallinder, Philip R.; Nicholls, David J.; Mete, Antonio; et al. Nature Chemical Biology, 2008, 4(11), 700-707. http://www.nature.com/nchembio/journal/v4/n11/abs/nchembio.115.html
- Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors--reducing the lipophilicity of the arachidonyl chain isostere. Walters, Iain; Bennion, Colin; Connolly, Stephen; Croshaw, Pamela J.; Hardy, Kim; Hartopp, Paul; Jackson, Clive G.; King, Sarah J.; Lawrence, Louise; Mete, Antonio; et al. Bioorganic & Medicinal Chemistry Letters, 2004, 14(14), 3645-3649. http://www.sciencedirect.com/science/article/pii/S0960894X04006596
- Preparation of aminohydroxyalkylthiothiophenecarbonitriles as nitric oxide synthase (NOS) inhibitors. Mete, Antonio; Walters, Iain; PCT Int. Appl. 2004, WO 2004009580.
- Preparation of 3-[((1S)-2-amino-1-phenylethyl)thio]-5-methyl-2-thiophenecarbonitrile oxalate and related compounds as nitric oxide synthase inhibitors. Mete, Antonio; Walters, Iain; PCT Int. Appl. 2004, WO 2004009579.
- Inhibitors of the NOS enzymes: a patent review. Mete, Antonio; Connolly, Stephen; IDrugs, 2003, 6(1), 57-65. http://www.ncbi.nlm.nih.gov/pubmed/12789622
- Preparation of heteroarylheteroalkylamines as inhibitors of nitric oxide synthase. Chen, Deborah; Cheshire, David; Connolly, Stephen; Mete, Antonio; PCT Int. Appl. 2003, WO 2003011831.
- Preparation of heteroarylheteroalkylamines as inhibitors of nitric oxide synthase. Birkinshaw, Timothy; Cheshire, David; ConnollyStephen; Luker, Timothy; Mete, Antonio; PCT Int. Appl.2003, WO 2003011830.
- Preparation of (hetero)arylheteroalkylamines as inhibitors of nitric oxide synthase. Cheshire, David; Connolly, Stephen; Mete, Antonio; PCT Int. Appl. 2003, WO 2003011210.
- Preparation of arylheteroalkylamine derivatives as nitric oxide synthase inhibitors useful as anti-inflammatories and analgesics.
Birkinshaw, Tim; Connolly, Stephen; Luker, Timothy; Mete, Antonio; Millichip, Ian; PCT Int. Appl. 2002, WO 2002090332.
- Preparation of phenylheteroazetidines useful as nitric oxide synthase inhibitors. Cheshire, David; Luker, Timothy; Mete, Antonio; PCT Int. Appl. 2002, WO 2002012187.
- Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 based on a 1,3-Disubstituted Propan-2-one Skeleton. Connolly, Stephen; Bennion, Colin; Botterell, Sarah; Croshaw, Pamela J.; Hallam, Catherine; Hardy, Kim; Hartopp, Paul; Jackson, Clive G.; King, Sarah J.; Lawrence, Louise; Mete, Antonio; et al. Journal of Medicinal Chemistry,2002, 45(6), 1348-1362. http://pubs.acs.org/doi/abs/10.1021/jm011050x?prevSearch=%255BContrib%253A%2Bmete%255D&searchHistoryKey
- Preparation of novel phenylheteroalkylamines as inhibitors of nitric oxide synthase. Cheshire, David; Connolly, Stephen; Cox, David; Mete, Antonio; PCT Int. Appl. 2001, WO 2001062714.
- Preparation of novel phenylheteroalkylamines as inhibitors of nitric oxide synthase. Birkinshaw, Tim; Cheshire, David; Mete, Antonio; PCT Int. Appl. 2001, WO 2001062713.
- Preparation of phenylheteroalkylamines as inhibitors of nitric oxide synthase. Cheshire, David; Connolly, Stephen; Cox, David; Hamley, Peter; Mete, Antonio; Pimm, Austen; PCT Int. Appl.2001, WO 2001062704.
- Preparation of 5,7-bicyclic amidine derivatives useful as nitric oxide synthase inhibitors. Cheshire, David; Connolly, Stephen; Cox, David; Hamley, Peter; Luker, Timothy; Mete, Antonio; Pimm, Austen; Stocks, Michael; PCT Int. Appl. 2000, WO 2000064904.
- 1,3-Disubstituted Propan-2-ones: A Novel Series of Potent Inhibitors of cPLA2. Mete, Antonio; Connolly, Stephen; et al. Poster at XVth EFMC International Symposium on Medicinal Chemistry, Edinburgh, 1998. (Reviewed in: Drugs of the Future, 2000, 25(8), 823-32).
- Preparation of aryloxyacyl thiazoles and their analogs as anti-inflammatory agents. Mete, Antonio; Connolly, Stephen; PCT Int. Appl. 2000, WO2000034254.
- Transition State Analogues as Inhibitors of cPLA2. Mete, Antonio; Connolly, Stephen; et al. Lecture at East of England Medicinal Chemistry Symposium, Hatfield, 1998.
Synthetic Methodology and Salt Formation
- A novel 4-methylbenzenesulphonate salt and a process for preparing a pharmaceutical composition comprising the salt. Mete, Antonio; Nilsson, Karolina; Nystroem, Stefan; Trofast, Eva; PCT Int. Appl. 2010, WO 2010144043.
- [(S)-2-Phenyl-2-(piperidin-1-yl)propanoyloxy]-(R)-1-azabicyclo[2.2.2]octane salt derivatives as muscarinic receptor antagonists and their preparation, pharmaceutical compositions and use in the treatment of respiratory diseases. Mete, Antonio; Millichip, Ian; PCT Int. Appl. 2009, WO 2009154554.
- Olefination of 3-diazopiperidin-2-one. Harrison, Richard; Mete, Antonio; Wilson, Lauren; Tetrahedron Letters, 2003, 44(35), 6621-6624. http://www.sciencedirect.com/science/article/pii/S0040403903016800
- Asymmetric synthesis of azidotetrahydropyranols via Sharpless epoxidation. Ong, Quyen; Handa, Sheetal; Mete, Antonio; Hill, Alison M.; Jones, Keith; ARKIVOC, 2002, (3), 176-187.
- The synthesis and chemistry of 3-diazo-piperidin-2-one. Hutchinson, Ian S.; Matlin, Stephen A.; Mete, Antonio; Tetrahedron, 2002,58(16), 3137-3143. http://www.sciencedirect.com/science/article/pii/S0040402002002788
- The synthesis of 3-diazo-2-(nitromethylene)piperidine. Hutchinson, I. S.; Matlin, S. A.; Mete, A. Tetrahedron Letters, 2001, 42(9), 1773-1776.
- Palladium catalysed amination of electron-deficient halothiophenes. Luker, T. J.; Beaton, H. G.; Whiting, M.; Mete, A.; Cheshire, D. R; Tetrahedron Letters, 2000, 41(40), 7731-7735. http://www.sciencedirect.com/science/article/pii/S0040403900013071
- Novel nucleoside analogues via direct attack of carbon nucleophiles on nucleosides containing epoxy sugars. Mete, A.; Hobbs, J. B.; Scopes, D. I. C.; Newton, R. F. Tetrahedron Letters, 1985, 26(1), 97-100. http://www.sciencedirect.com/science/article/pii/S0040403900984776
- A novel 4-methylbenzenesulphonate salt and a process for preparing a pharmaceutical composition comprising the salt. Mete, Antonio; Nilsson, Karolina; Nystroem, Stefan; Trofast, Eva; PCT Int. Appl. 2010, WO 2010144043.
- [(S)-2-Phenyl-2-(piperidin-1-yl)propanoyloxy]-(R)-1-azabicyclo[2.2.2]octane salt derivatives as muscarinic receptor antagonists and their preparation, pharmaceutical compositions and use in the treatment of respiratory diseases. Mete, Antonio; Millichip, Ian; PCT Int. Appl. 2009, WO 2009154554.
- Olefination of 3-diazopiperidin-2-one. Harrison, Richard; Mete, Antonio; Wilson, Lauren; Tetrahedron Letters, 2003, 44(35), 6621-6624. http://www.sciencedirect.com/science/article/pii/S0040403903016800
- Asymmetric synthesis of azidotetrahydropyranols via Sharpless epoxidation. Ong, Quyen; Handa, Sheetal; Mete, Antonio; Hill, Alison M.; Jones, Keith; ARKIVOC, 2002, (3), 176-187.
- The synthesis and chemistry of 3-diazo-piperidin-2-one. Hutchinson, Ian S.; Matlin, Stephen A.; Mete, Antonio; Tetrahedron, 2002,58(16), 3137-3143. http://www.sciencedirect.com/science/article/pii/S0040402002002788
- The synthesis of 3-diazo-2-(nitromethylene)piperidine. Hutchinson, I. S.; Matlin, S. A.; Mete, A. Tetrahedron Letters, 2001, 42(9), 1773-1776.
- Palladium catalysed amination of electron-deficient halothiophenes. Luker, T. J.; Beaton, H. G.; Whiting, M.; Mete, A.; Cheshire, D. R; Tetrahedron Letters, 2000, 41(40), 7731-7735. http://www.sciencedirect.com/science/article/pii/S0040403900013071
- Novel nucleoside analogues via direct attack of carbon nucleophiles on nucleosides containing epoxy sugars. Mete, A.; Hobbs, J. B.; Scopes, D. I. C.; Newton, R. F. Tetrahedron Letters, 1985, 26(1), 97-100. http://www.sciencedirect.com/science/article/pii/S0040403900984776